Yang X. and Tohda C.
Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer’s disease model mice.
Molecular Psychiatry (2023) 28, 2398-2411.

Nakano A, Yang X, Kuboyama T, Inada Y, Tohda C.
Intrathecal infusion of diosgenin during the chronic phase of spinal cord injury ameliorates motor function and axonal density.
Neurochem J (2021) 15(4), 454-461.

東田 千尋, 楊 熙蒙, 野本 かおり
日本食品化学学会誌 27巻(2020)2号Yang X, Tohda C.
Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70).
Scientific Reports, (2018) 8(1), 11707. doi: 10.1038/s41598-018-30102-8.

生体の科学, (2018) 第69巻4号 354-357.Yang X, Tohda C.
Heat Shock Cognate 70 inhibitor, VER-155008, reduces memory deficits and axonal degeneration in a mouse model of Alzheimer’s disease.
Frontiers in Pharmacology, (2018) 9, 48. doi: 10.3389/fphar.2018.00048.Tohda C, Yang X, Matsui M, Inada Y, Kadomoto E, Nakada S, Watari H, Shibahara N.
Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults.
Nutrients, (2017) 9(10), 1160. doi:10.3390/nu9101160Tohda C.
New age therapy for Alzheimer’s disease by neuronal network reconstruction. Biol Pharm Bull, (2016) 39(10), 1569-1575. doi: 10.1248/bpb.b16-00438東田千尋、久保山友晴.
日本薬理学雑誌, (2014) 143, 73-77.Tohda C, Lee Y-A, Goto Y, Nemere I.
Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS.
Scientific Reports, (2013) Dec 2;3:3395. doi: 10.1038/srep03395.Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T.
Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice.
Scientific Reports, (2012) 2, 535. DOI:10.1038/srep00535